Same riff, 6 different guitars, same effects and amp settings

[Vivek]

Interesting YouTube showing different sounds created due to different guitars, all other things remaining constant.

[ElectricDruid]

Interesting YouTube showing different sounds created due to different guitars, all other things remaining constant.

Given the hugely varying output levels, not to mention the tone differences between humbuckers and single coil pickups, I'm not surprised this makes a significant difference.
Still, it's nice to hear a direct comparison like this.